While bioprocesses using Escherichia coli, Corynebacterium glutamicum, different bacillus and lactic acid bacteria, and clostridia, the yeasts Saccharomyces cerevisiae and Pichia pastoris as well as Chinese hamster ovary cells are widely established, the high microbial diversity has not yet been technical exploited. However, the use of alternative organisms can considerably extend the process window of bioprocesses. The extensions can include the utilization of alternative substrates such as CO2 or methane, unusual process conditions (temperatures, media conditions), or the exploitation of the microbial diversity (biofilm growth, alternative electron transport systems), itself. A variety of unusual organisms are currently being investigated. Bringing these hidden champions into application will enable more efficient processes with environmental and ecological benefits. Here, the current progress in the development of processes based on the alternative organisms is presented. In all chapters, first the microbiological and biochemical special features of the organisms are described. Afterwards, typical biotechnological processes based on the organisms are discussed. Finally, the current challenges and future trends in the application of the organisms are highlighted.

Autorentext

Study of Chemical engineering/biotechnology; PhD thesis Electrochemical monitoring of microbial activity - basics and application in wastewater treatment", University of Magdeburg, 01/1999 09/201 DECHEMA Research Institute, Frankfurt am Main, final position Group Leader "Industrial Biotechnology", 10/2019 03/2023 W2-Professor "Intensification of Bioprocesses", Technische Hochschule Mittelhessen, Gießen, Since 04/2023 W3-Professor "Electrobiotechnology , Karlsruher Institut für Technologie (KIT)

Inhalt

Unconventional Production Organisms in Biotechnology - Opportunities and Needs.- Methanothermobacter thermautotrophicus and alternative methanogens - archaea-based production.- Cupriavidus necator - a "knallgas" bacterium.- Vibrio natriegens - application of a fast-growing halotolerant bacterium.- Shewanella oneidensis - biotechnological application of a metal-reducing bacteria.- Pseudomonas taiwanensis and Pseudomonas putida - solvent tolerant bacteria.- Synechocystis sp. PCC6803 and Synechococcus UTEX - biotechnological applications of cyanobacteria.- Cable-bacteria and their biotechnological application.- Parageobacillus thermoglucosidasius - application of a carboxydotrophic bacteria.- Dictyostelium discoideum - Amoebae as potential host organisms for complex substances.- Bioproduction with the mixotroph algae Euglena gracilis.