This book represents the synthesis of many current cancer theories, which combined, offers a novel and innovative approach in the diagnosis, prevention, and treatment of cancer. It introduces a new and different paradigm in the diagnosis, prevention, and treatment of cancer, by taking into account the organism as a whole, which is very different from the current cellular/tissular approach toward cancer. In this new paradigm, cancer involves dynamic interactions with the entire body and its internal milieu. Focusing on these interactions will permit pre-clinical cancer diagnosis and novel treatment approaches.

This onco-holobiont model integrates most of the current malignant process models and it is intended for the use of practitioners/clinicians, cancer researchers, and students with a particular interest in cancer. The goal of this book is to inspire scientists to go beyond the current methods in the treatment of cancer and discover new paradigms.

Autorentext

Doru Paul M.D., PhD
Associate Professor of Clinical Medicine
Weill Cornell Medical College
New York-Presbyterian Hospital
Department of Medicine
Division of Hematology/Oncology
New York, NY

Dr. Paul received his MD from the Carol Davila Faculty of Medicine in Bucharest, Romania and his PhD from the Faculty of Medicine in Craiova, Romania. He also got diplomas in Clinical Oncology, Chronobiology and Biology of Aging from Paris, France and he completed his training in Internal Medicine, Hematology and Medical Oncology in New York. Dr. Paul is an experienced clinician with more than ten thousand cancer patients treated until now and with a strong background in basic and translational research. He has designed and conducted several investigator initiated studies and initiated three FDA approved investigational new drug studies including the first in-man pilot study that uses [18F] Fluorodeoxyglucose (FDG) for the targeted treatment of cancer. Since 2015, he has been working on a novel cancer model [see, for example The systemic hallmarks of cancer (2020) and Cancer as a form of life: Musings of the cancer and evolution symposium (2021). He is also the senior oncology editor of the verywellhealth.com website and the editor-in-chief of the Journal of Medical and Radiation Oncology.

Inhalt

1. Introduction.- 2. One Flew Over the Cancer s Nest.- 3. Cancer Significance.- 4. Cancer Theories.- 5. The Main Cancer Theories in Focus.- 6. From Being to Becoming: Philosophical Echoes in the Biology of Life and Cancer.- 7. Life Theories.- 8. The Homeodynamic Theory of Life: An Introduction.- 9. Homeodynamic Laws and Life Principles.- 10. Biological Time.- 11. The Temporal Landmarks of Cancer.- 12. The Path to Cancer Cure.- 13. Real-Time Adaptive Cancer Therapies Guided by Longitudinal Biomarkers, Multiomics Integration, and Artificial Intelligence Assisted Strategies.- 14. The Essential Integration: Patient Oriented Oncology.- 15. Conclusions.